Ethyl Acrylate → Ethyl 3-(ethoxycarbonylmethylamino)propionate
반응식
[OH-].[Na+].Cl.[NH2:4][CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7].[C:11]([O:15][CH2:16][CH3:17])(=[O:14])[CH:12]=[CH2:13]>O>[CH2:9]([O:8][C:6]([CH2:5][NH:4][CH2:13][CH2:12][C:11]([O:15][CH2:16][CH3:17])=[O:14])=[O:7])[CH3:10]참가 물질
5
실험 절차
A 4.7M aqueous solution of sodium hydroxide (50 mL) was added into a stirred, ice-cooled solution of ethyl glycinate hydrochloride (32.19 g, 0.23 mole) in water (50 mL). Then, ethyl acrylate (23.1 g, 0.23 mole) was added and the mixture was stirred at room temperature until the completion of reaction was ascertained by TLC (19 h). After 19 h which it was partitioned with dichloromethane (3×100 mL). The organic layer was dried with anhydrous sodium sulfate, filtered and evaporated. The residue was distilled to afford AA (28.8 g, 61%).
후처리
- customwas ascertained by TLC (19 h)
- customAfter 19 h which it was partitioned with dichloromethane (3×100 mL)
- dry with materialThe organic layer was dried with anhydrous sodium sulfate
- filtrationfiltered
- customevaporated
- distillationThe residue was distilled
- customto afford AA (28.8 g, 61%)
출처 및 근거
- ORD 기록
- ord-52b52b1c24a64847a3cd38a59d3ea0ba
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07745608B2
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