Ammonia → 5-Bromo-3-iodo-4-methylpyridin-2-amine
반응식
[Br:1][C:2]1[C:3]([CH3:9])=[CH:4][C:5]([NH2:8])=[N:6][CH:7]=1.[I:10]N1C(=O)CCC1=O.FC(F)(F)C(O)=O.N>C(O)(=O)C>[Br:1][C:2]1[C:3]([CH3:9])=[C:4]([I:10])[C:5]([NH2:8])=[N:6][CH:7]=1참가 물질
6
실험 절차
5-Bromo-4-methylpyridine-2-amine (3.1 g) was dissolved in acetic acid (20 ml). N-Iodosuccinimide (3.8 g) and trifluoroacetic acid (0.2 ml) were added and the mixture was stirred at room temperature for 2.5 hours. The reaction solution was poured into ice water and neutralized with 28% aqueous ammonia. Then, the precipitated solid was collected by filtration, washed with water and dried to give the title compound (4.9 g).
후처리
- filtrationThen, the precipitated solid was collected by filtration
- washwashed with water
- customdried
출처 및 근거
- ORD 기록
- ord-828b4177bc2d4c569dad569a1bb7cb65
- 출처 데이터셋
- uspto-grants-2013_05
- 특허 번호
- US08436012B2
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