Water → 7-pyrrolidin-1-yl-3,4-dihydro-2H-naphthalen-1-ol

HRID 2089475노트

반응식

HRID 2089475 반응식
[N:1]1([C:6]2[CH:15]=[C:14]3[C:9]([CH2:10][CH2:11][CH2:12][C:13]3=[O:16])=[CH:8][CH:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[BH4-].[Na+].O>CO>[N:1]1([C:6]2[CH:15]=[C:14]3[C:9]([CH2:10][CH2:11][CH2:12][CH:13]3[OH:16])=[CH:8][CH:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 591994477-pyrrolidin-1-yl-3,4-dihydro-2H-naphthalen-1-one

생성물 1

HCID 675492557-pyrrolidin-1-yl-3,4-dihydro-2H-naphthalen-1-ol

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 7-pyrrolidin-1-yl-3,4-dihydro-2H-naphthalen-1-one (0.548 g, 2.55 mmol) in methanol (20 mL) at 0° C. is added sodium borohydride (0.241 g, 3.54 mmol) and the reaction is stirred for 1.5 hours, whereupon water is added and the volatiles are removed in vacuo. The mixture is extracted with dichloromethane. The organic phase is dried over sodium sulfate, filtered, and concentrated to give 7-pyrrolidin-1-yl-3,4-dihydro-2H-naphthalen-1-ol, which is used in the next step without further purification.

후처리

  1. additionis added
  2. customthe volatiles are removed in vacuo
  3. extractionThe mixture is extracted with dichloromethane
  4. dry with materialThe organic phase is dried over sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-099b40a8097e4746a0f7dfce6f449449
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08436035B2

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