Cyclopentanone → 7-(Cyclopentyl)amino-2-phenyl-1H-indole-5-carboxylic acid ethyl ester

반응식

[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[C:8]2[C:12](=[C:13]([N+:15]([O-])=O)[CH:14]=1)[NH:11][C:10]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[CH:9]2)=[O:5])[CH3:2].[C:24]1(=O)[CH2:28][CH2:27][CH2:26][CH2:25]1>>[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[C:8]2[C:12](=[C:13]([NH:15][CH:24]3[CH2:28][CH2:27][CH2:26][CH2:25]3)[CH:14]=1)[NH:11][C:10]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[CH:9]2)=[O:5])[CH3:2]

참가 물질

반응물 2

HCID 8452Cyclopentanone

HCID 68474038ethyl 7-nitro-2-phenyl-1H-indole-5-carboxylate

생성물 1

HCID 252139517-(Cyclopentyl)amino-2-phenyl-1H-indole-5-carboxylic acid ethyl ester

실험 절차

2-Phenyl-7-nitro-1H-indole-5-carboxylic acid ethyl ester prepared in Step A and cyclopentanone were reacted according to the same procedure as Example 1 to give the title compound.

출처 및 근거

ORD 기록: ord-ac878fd8bd194da98863d9453a1f4c18
출처 데이터셋: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08436038B2

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