Dimethylamine, hydrochloride → 2-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-N,N-dimethyl-1,2,3,4-tetrahydroisoquinoline-7-carboxamide

HRID 2090313노트

반응식

HRID 2090313 반응식
[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:17][CH2:16][C:15]3[C:10](=[CH:11][C:12]([C:18](O)=[O:19])=[CH:13][CH:14]=3)[CH2:9]2)[CH:5]=[C:4]([N:21]2[CH2:26][CH2:25][N:24]([CH3:27])[CH2:23][CH2:22]2)[N:3]=1.Cl.[CH3:29][NH:30][CH3:31]>>[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:17][CH2:16][C:15]3[C:10](=[CH:11][C:12]([C:18]([N:30]([CH3:31])[CH3:29])=[O:19])=[CH:13][CH:14]=3)[CH2:9]2)[CH:5]=[C:4]([N:21]2[CH2:22][CH2:23][N:24]([CH3:27])[CH2:25][CH2:26]2)[N:3]=1

참가 물질

3

반응물 2

HCID 10473Dimethylamine, hydrochlorideHCID 594022702-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid

생성물 1

HCID 467013862-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-N,N-dimethyl-1,2,3,4-tetrahydroisoquinoline-7-carboxamide

실험 절차

This compound was prepared by using procedures analogous to those described for the synthesis of Example 18 starting from 2-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid and dimethylamine hydrochloride (Aldrich Cat. No. 391956).

후처리

  1. customThis compound was prepared

출처 및 근거

ORD 기록
ord-762bfbef810040af9f4b2424a225b053
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08436008B2

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