Hydrochloric Acid → Isobutyric acid (1s,2s)-6-fluoro-2-[2-({3-[(2-fluoro-ethyl)-(3-methoxy-2-methoxymethyl-2-methyl-propyl)-amino]-propyl}-methyl-amino)-ethyl]-1-isopropyl-1,2,3,4-tetrahydro-naphthalen-2-yl ester dihydrochloride salt

HRID 2090574노트

반응식

HRID 2090574 반응식
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C@H:8]([CH:12]([CH3:14])[CH3:13])[C@@:7]([O:35][C:36](=[O:40])[CH:37]([CH3:39])[CH3:38])([CH2:15][CH2:16][N:17]([CH2:19][CH2:20][CH2:21][N:22]([CH2:32][CH2:33][F:34])[CH2:23][C:24]([CH2:29][O:30][CH3:31])([CH3:28])[CH2:25][O:26][CH3:27])[CH3:18])[CH2:6][CH2:5]2.[ClH:41]>CCOC(C)=O>[ClH:41].[ClH:41].[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C@H:8]([CH:12]([CH3:14])[CH3:13])[C@@:7]([O:35][C:36](=[O:40])[CH:37]([CH3:39])[CH3:38])([CH2:15][CH2:16][N:17]([CH2:19][CH2:20][CH2:21][N:22]([CH2:32][CH2:33][F:34])[CH2:23][C:24]([CH2:29][O:30][CH3:31])([CH3:28])[CH2:25][O:26][CH3:27])[CH3:18])[CH2:6][CH2:5]2

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 45381136isobutyric acid (1S,2S)-6-fluoro-2-[2-({3-[(2-fluoro-ethyl)-(3-methoxy-2-methoxymethyl-2-methyl-propyl)-amino]-propyl}-methyl-amino)-ethyl]-1-isopropyl-1,2,3,4-tetrahydro-naphthalen-2-yl ester

생성물 1

HCID 86657122Isobutyric acid (1s,2s)-6-fluoro-2-[2-({3-[(2-fluoro-ethyl)-(3-methoxy-2-methoxymethyl-2-methyl-propyl)-amino]-propyl}-methyl-amino)-ethyl]-1-isopropyl-1,2,3,4-tetrahydro-naphthalen-2-yl ester dihydrochloride salt

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

411 mg of isobutyric acid (1S,2S)-6-fluoro-2-[2-({3-[(2-fluoro-ethyl)-(3-methoxy-2-methoxymethyl-2-methyl-propyl)-amino]-propyl}-methyl-amino)-ethyl]-1-isopropyl-1,2,3,4-tetrahydro-naphthalen-2-yl ester were dissolved in 10 mL EtOAc, the solution was cooled with an ice bath and 2.4 mL of 3M HCl in EtOAC were added. The reaction mixture was evaporated to dryness without heating to give the desired isobutyric acid (1S,2S)-6-fluoro-2-[2-({3-[(2-fluoro-ethyl)-(3-methoxy-2-methoxymethyl-2-methyl-propyl)-amino]-propyl}-methyl-amino)-ethyl]-1-isopropyl-1,2,3,4-tetrahydro-naphthalen-2-yl ester dihydrochloride salt.

후처리

  1. temperaturethe solution was cooled with an ice bath
  2. customThe reaction mixture was evaporated to dryness
  3. temperaturewithout heating

출처 및 근거

ORD 기록
ord-8d691f5156da42f4949101d52fe5495e
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08436205B2

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