Phenol → HCID 66779142, 화합물

HRID 2091137노트

반응식

HRID 2091137 반응식
Br[CH2:2][C:3]([C:5]1[O:6][C:7]2[CH:14]=[CH:13][CH:12]=[CH:11][C:8]=2[C:9]=1[CH3:10])=[O:4].[C:15]1([OH:21])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.C(=O)([O-])[O-].[K+].[K+].[Cl-].[NH4+]>CN(C)C=O>[CH3:10][C:9]1[C:8]2[CH:11]=[CH:12][CH:13]=[CH:14][C:7]=2[O:6][C:5]=1[C:3](=[O:4])[CH2:2][O:21][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

참가 물질

6

반응물 4

HCID 996PhenolHCID 11430Potassium CarbonateHCID 25517Ammonium ChlorideHCID 38482132-Bromo-1-(3-methyl-1-benzofuran-2-yl)ethan-1-one

생성물 1

HCID 66779142HCID 66779142, 화합물수율 66.2%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a mixture of 2-bromo-1-(3-methyl-1-benzofuran-2-yl)ethanone (1.00 g), phenol (446 mg) and N,N-dimethylformamide (20 mL) was added potassium carbonate (655 mg), and the mixture was stirred overnight at room temperature. Saturated aqueous ammonium chloride solution was added to quench the reaction, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (10% ethyl acetate/hexane) to give the title object compound (697 mg, 66%) as a yellow solid.

후처리

  1. customto quench
  2. customthe reaction
  3. extractionthe mixture was extracted with ethyl acetate
  4. washThe extract was washed with saturated brine
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated under reduced pressure
  7. customThe residue was purified by silica gel column chromatography (10% ethyl acetate/hexane)

출처 및 근거

ORD 기록
ord-c5f1201b16c64da08c07cb39b1c6dd7e
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08436043B2

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