Water → 1-(5-Fluoro-3-methyl-1-benzofuran-2-yl)-2-methylpropan-1-ol

HRID 2091404노트

반응식

HRID 2091404 반응식
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10](=[O:14])[CH:11]([CH3:13])[CH3:12])=[C:7]([CH3:15])[C:6]=2[CH:16]=1.[BH4-].[Na+].O>CO.O1CCCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([CH:10]([OH:14])[CH:11]([CH3:12])[CH3:13])=[C:7]([CH3:15])[C:6]=2[CH:16]=1

참가 물질

6

반응물 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 667778481-(5-Fluoro-3-methyl-1-benzofuran-2-yl)-2-methylpropan-1-one

생성물 1

HCID 667782941-(5-Fluoro-3-methyl-1-benzofuran-2-yl)-2-methylpropan-1-ol수율 100%

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

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온도
0 °C

실험 절차

1-(5-Fluoro-3-methyl-1-benzofuran-2-yl)-2-methylpropan-1-one (11.66 g) synthesized above was dissolved in methanol (4 mL)-tetrahydrofuran (20 mL), and sodium tetrahydroborate (90%) (446 mg) was added to the solution at 0° C. The reaction mixture was stirred at 0° C. for 1 hr. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate. After filtration, the filtrate was concentrated to give the title compound (1.193 g, 100%) as a colorless oil.

후처리

  1. additionwas added to the solution at 0° C
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed with saturated brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. filtrationAfter filtration
  6. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-043773e47d9b4a219fafa5132db18734
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08436043B2

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