Ethanol → 1-Tetradecyl-3-ethylglycerol

HRID 2091489

반응식

HRID 2091489 반응식
[O-:1][CH2:2][CH3:3].[Na+].C(O)C.[CH2:8]([O:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH:9]1[O:11][CH2:10]1>>[CH2:13]([O:12][CH2:8][CH:9]([CH2:10][O:1][CH2:2][CH3:3])[OH:11])[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26]

참가 물질

4

반응물 3

HCID 702EthanolHCID 38190Oxirane, 2-((tetradecyloxy)methyl)-HCID 2723922Sodium ethoxide

생성물 1

HCID 866529161-Tetradecyl-3-ethylglycerol수율 319.6%

반응 조건

온도
80 °C

실험 절차

Under nitrogen stream, 30 g of sodium ethoxide was added to 851.8 g (18.5 mol) of ethanol, and the mixture was heated to 80° C. Then, 500 g (1.85 mol) of tetradecyl glycidyl ether were added dropwise thereto. The mixture was stirred for 18 hours at the same temperature. Thereafter, ethanol was distilled off, and 10.8 g of 85% phosphoric acid was added thereto, followed by washing the resultant mixture with water three times. After water washing, distillation was performed under reduced pressure, to thereby obtain 446 g of 1-tetradecyl-3-ethylglycerol (yield 76.2%).

후처리

  1. distillationThereafter, ethanol was distilled off
  2. addition10.8 g of 85% phosphoric acid was added
  3. washby washing the resultant mixture with water three times
  4. distillationAfter water washing, distillation

출처 및 근거

ORD 기록
ord-7de36ed9740c418595431acf70cab376
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08440645B2

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