Hydrazine hydrate (1:1) → 4-bromo-N-(5-(hydrazinecarbonyl)thiophen-3-yl)picolinamide
반응식
[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]([NH:10][C:11]2[CH:12]=[C:13]([C:16]([O:18]C)=O)[S:14][CH:15]=2)=[O:9])[CH:3]=1.O.[NH2:21][NH2:22]>C(O)C>[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]([NH:10][C:11]2[CH:12]=[C:13]([C:16]([NH:21][NH2:22])=[O:18])[S:14][CH:15]=2)=[O:9])[CH:3]=1참가 물질
4
실험 절차
The methyl 4-(4-bromopicolinamido)thiophene-2-carboxylate (2.7 g, 6.9 mmol) was dissolved in ethanol, hydrazine hydrate (1.4 mL, 28 mmol) was added and the reaction was refluxed overnight. The reaction mixture was concentrated, and the solids were suspended in acetonitrile and filtered to afford 2.4 g (70%) 4-bromo-N-(5-(hydrazinecarbonyl)thiophen-3-yl)picolinamide as a white solid. M+1=341.1
후처리
- temperaturethe reaction was refluxed overnight
- concentrationThe reaction mixture was concentrated
- filtrationfiltered
출처 및 근거
- ORD 기록
- ord-8e3c567faaa84e1ebc8cbb177885228e
- 출처 데이터셋
- uspto-grants-2013_05
- 특허 번호
- US08440665B2
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