Sodium Hydroxide → HCID 57770667, 화합물

HRID 2091823노트

반응식

HRID 2091823 반응식
C[O:2][C:3](=[O:26])[C:4]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][N:11]=2)[CH:7]=[C:6]([C:17]2[N:18]([CH2:22][CH:23]3[CH2:25][CH2:24]3)[N:19]=[CH:20][CH:21]=2)[CH:5]=1.[OH-].[Na+]>CO>[CH:23]1([CH2:22][N:18]2[C:17]([C:6]3[CH:5]=[C:4]([CH:9]=[C:8]([C:10]4[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][N:11]=4)[CH:7]=3)[C:3]([OH:26])=[O:2])=[CH:21][CH:20]=[N:19]2)[CH2:25][CH2:24]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 57770606HCID 57770606, 화합물

생성물 1

HCID 57770667HCID 57770667, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

3-(2-Cyclopropylmethyl-2H-pyrazol-3-yl)-5-(5-methyl-pyridin-2-yl)-benzoic acid methyl ester (1.14 g, 3.27 mmol was dissolved in 20 mL MeOH, and 3N aqueous NaOH (3 mL) was added. The reaction mixture was stirred at room temperature for three hours, then concentrated under reduced pressure. The residue was acidified to pH 3 and extracted with EtOAc. The combined organic layers were dried over MgSO4, filtered and concentrated under reduced pressure to give 0.9 g of 3-(2-cyclopropylmethyl-2H-pyrazol-3-yl)-5-(5-methyl-pyridin-2-yl)-benzoic acid, MS (M+H)=334.

후처리

  1. concentrationconcentrated under reduced pressure
  2. extractionextracted with EtOAc
  3. dry with materialThe combined organic layers were dried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-4ebe2dfed5a1417cb4d39114c2b83188
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08440673B2

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