Hydrochloric Acid → 5-benzyloctahydro-1H-pyrrolo[3,4-c]pyridine-2,5-diium chloride

HRID 2092211노트

반응식

HRID 2092211 반응식
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]2[CH2:14][N:15](C(OC(C)(C)C)=O)[CH2:16][CH:10]2[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:24].C(OCC)C>C(O)C.C(O)(C)C>[Cl-:24].[CH2:1]([NH+:8]1[CH2:13][CH2:12][CH:11]2[CH2:14][NH2+:15][CH2:16][CH:10]2[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-:24]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 68725101tert-butyl 5-benzylhexahydro-1H-pyrrolo[3,4-c]pyridine-2(3H)-carboxylate

생성물 1

HCID 866476885-benzyloctahydro-1H-pyrrolo[3,4-c]pyridine-2,5-diium chloride

시약·촉매·용매 2

HCID 702Ethanol용매HCID 3776Isopropanol용매

실험 절차

1.355 g of tert-butyl 5-benzylhexahydro-1H-pyrrolo[3,4-c]pyridine-2(3H)-carboxylate (4.28 mmol) were dissolved in 10 ml of ethanol. To the solution 20 ml of 5 N HCl in isopropanol were added and the obtained mixture was stirred at room temperature for 16 h. After addition of diethyl ether the product precipitated. The product was filtered and after an additional washing with diethyl ether, the product was dried. Additional product was obtained by concentration of the filtrates and crystallization from diethyl ether. Combined amounts of product were 1.07 g.

후처리

  1. customprecipitated
  2. filtrationThe product was filtered
  3. washafter an additional washing with diethyl ether
  4. customthe product was dried
  5. customAdditional product was obtained by concentration of the filtrates and crystallization from diethyl ether

출처 및 근거

ORD 기록
ord-880c6940d7a44c1bb8358e884d191516
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08440694B2

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