Hydrochloric Acid → Methyl 2-(4-chlorophenyl)-4-(hydroxymethyl)-1,3-oxazole-5-carboxylate

HRID 2092250노트

반응식

HRID 2092250 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([C:18]([O:20][CH3:21])=[O:19])=[C:11]([CH2:13][O:14]COC)[N:12]=2)=[CH:4][CH:3]=1.Cl>CO.Cl.O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:9][C:10]([C:18]([O:20][CH3:21])=[O:19])=[C:11]([CH2:13][OH:14])[N:12]=2)=[CH:6][CH:7]=1

참가 물질

6

반응물 2

HCID 313Hydrochloric AcidHCID 58284400Methyl 2-(4-chlorophenyl)-4-[(methoxymethoxy)methyl]-1,3-oxazole-5-carboxylate

생성물 1

HCID 58284345Methyl 2-(4-chlorophenyl)-4-(hydroxymethyl)-1,3-oxazole-5-carboxylate

시약·촉매·용매 3

HCID 313Hydrochloric Acid촉매HCID 887Methanol용매HCID 962Water용매

실험 절차

144 mg (0.52 mmol) of the compound from Example 43A are initially charged in 0.5 ml of methanol, and 0.13 ml of 4 N hydrochloric acid are added. 3 drops of conc. hydrochloric acid are then added. The reaction mixture is stirred at RT for 8 h. The mixture is then diluted with about 5 ml of water and extracted three times with in each case 10 ml of diethyl ether. The combined organic phases are dried over magnesium sulfate and the solvent is removed on a rotary evaporator. The product obtained is used without further purification in the subsequent reaction.

후처리

  1. extractionextracted three times with in each case 10 ml of diethyl ether
  2. dry with materialThe combined organic phases are dried over magnesium sulfate
  3. customthe solvent is removed on a rotary evaporator
  4. customThe product obtained
  5. customis used without further purification in the subsequent reaction

출처 및 근거

ORD 기록
ord-2435f26a33c24cbd9fa774d2e50aad87
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08440700B2

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