o-Fluoroacetophenone → (1S)-1-(2-Fluorophenyl)ethan-1-ol

HRID 2092463노트

반응식

HRID 2092463 반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:10])[CH3:9].B1(C)OC(C2C=CC=CC=2)(C2C=CC=CC=2)[C@@H]2N1CCC2>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C@@H:8]([OH:10])[CH3:9]

참가 물질

3

반응물 2

HCID 96744o-FluoroacetophenoneHCID 9838490(R)-2-Methyl-CBS-oxazaborolidine

생성물 1

HCID 7023576(1S)-1-(2-Fluorophenyl)ethan-1-ol

실험 절차

(S)-1-(2-Fluoro-phenyl)-ethanol was prepared according to the procedure described in Example 35, Step 1 using 2′-fluoroacetophenone and (R)-(+)-2-methyl-CBS-oxazaborolidine.

출처 및 근거

ORD 기록
ord-d9f7d35eeec04245ae8bc4d84a1628ca
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08440707B2

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