Nitro-4-(2,2,2-trifluoro-1-methyl-ethoxy)-benzene → 4-(2,2,2-Trifluoro-1-methyl-ethoxy)-aniline

HRID 2092687

반응식

HRID 2092687 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][CH:11]([CH3:16])[C:12]([F:15])([F:14])[F:13])=[CH:6][CH:5]=1)([O-])=O>CO.[Pd]>[F:13][C:12]([F:14])([F:15])[CH:11]([CH3:16])[O:10][C:7]1[CH:6]=[CH:5][C:4]([NH2:1])=[CH:9][CH:8]=1

참가 물질

4

반응물 1

HCID 66577895Nitro-4-(2,2,2-trifluoro-1-methyl-ethoxy)-benzene

생성물 1

HCID 662775684-(2,2,2-Trifluoro-1-methyl-ethoxy)-aniline수율 98.6%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

Nitro-4-(2,2,2-trifluoro-1-methyl-ethoxy)-benzene (6.74 g) was dissolved in MeOH (70 mL). Pd on carbon (10% Pd, 500 mg) was added and the mixture was hydrogenated at RT for 12 hours. The suspension was filtered and the filtrate was concentrated in vacuo to provide the title compound as a brown liquid (5.8 g). Rf: 0.38 (silica gel, ether/heptane 1:1). MS (m/e): 206.1 (MH+).

후처리

  1. filtrationThe suspension was filtered
  2. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-2d8ee7dcd7514d0fa0a82721d3c39024
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08440710B2

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