Hydrochloric Acid → Erlotinib Hydrochloride
반응식
[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]2[C:20]([NH:21][C:22]3[CH:23]=[CH:24][CH:25]=[C:26]([C:28]#[CH:29])[CH:27]=3)=[N:19][CH:18]=[N:17][C:9]2=[CH:10][C:11]=1[O:12][CH2:13][CH2:14][O:15][CH3:16].FC(F)(F)C([O-])=O.[ClH:37]>C(O)(C)C>[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]2[C:20]([NH:21][C:22]3[CH:23]=[CH:24][CH:25]=[C:26]([C:28]#[CH:29])[CH:27]=3)=[N:19][CH:18]=[N:17][C:9]2=[CH:10][C:11]=1[O:12][CH2:13][CH2:14][O:15][CH3:16].[ClH:37]참가 물질
4
실험 절차
Erlotinib trifluoroacetate salt (10 g) was charged in to isopropyl alcohol (60 ml) at 25° C. to 30° C. 7.5% isopropanolic hydrochloride (13 ml) was added slowly to the reaction mixture at 25° C. to 30° C. and stirred for about 2 hours at 25° C. to 30° C. The solid obtained was filtered, washed with DI water (2×15 ml), suck dried and dried under vacuum for about 18 hours at 40° C. to 45° C. to give erlotinib hydrochloride.