Water → N-[4-(Propan-2-yl)phenyl]ethanimidic acid

HRID 2093037노트

반응식

HRID 2093037 반응식
[CH:1]([C:4]1[CH:10]=[CH:9][C:7]([NH2:8])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].C(N(CC)CC)C.[C:18](OC(=O)C)(=[O:20])[CH3:19].O>ClCCl>[CH:1]([C:4]1[CH:10]=[CH:9][C:7]([NH:8][C:18](=[O:20])[CH3:19])=[CH:6][CH:5]=1)([CH3:3])[CH3:2]

참가 물질

6

반응물 4

HCID 962WaterHCID 74644-IsopropylanilineHCID 7918Acetic AnhydrideHCID 8471Triethylamine

생성물 1

HCID 258025N-[4-(Propan-2-yl)phenyl]ethanimidic acid수율 95%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a solution of 4-isopropylaniline (1.0 eq) in dichloromethane at 0° C., triethylamine (2.2 eq) was added and stirred for 15 min. Then, acetic anhydride (1.0 eq) in dichloromethane was added at 0° C., after addition the reaction was continued at room temperature for 5 hrs. Water was added and the organic layer was separated, dried over anhydrous Na2SO4, concentrated under reduced pressure to afford crude product, which, on purification by column chromatography afforded the desired N-(4-isopropylphenyl)acetamide. (Yield=95%)

후처리

  1. additionafter addition the reaction
  2. waitwas continued at room temperature for 5 hrs
  3. customthe organic layer was separated
  4. dry with materialdried over anhydrous Na2SO4
  5. concentrationconcentrated under reduced pressure
  6. customto afford crude product, which
  7. customon purification by column chromatography

출처 및 근거

ORD 기록
ord-94693ed26b72423c9b046dfbbbc15112
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08440830B2

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