Water → 4-Amino-N,N-dimethyl-3-nitroaniline

HRID 2093042

반응식

HRID 2093042 반응식
[CH3:1][N:2]([CH3:16])[C:3]1[CH:8]=[CH:7][C:6]([NH:9]C(=O)C)=[C:5]([N+:13]([O-:15])=[O:14])[CH:4]=1.O.[OH-].[K+]>CO>[NH2:9][C:6]1[CH:7]=[CH:8][C:3]([N:2]([CH3:16])[CH3:1])=[CH:4][C:5]=1[N+:13]([O-:15])=[O:14]

참가 물질

5

반응물 3

HCID 962Water2회HCID 14797Potassium HydroxideHCID 4396139N-[4-(dimethylamino)-2-nitrophenyl]acetamide

생성물 1

HCID 27334524-Amino-N,N-dimethyl-3-nitroaniline수율 65%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of N-[4-(dimethylamino)-2-nitrophenyl]acetamide obtained in step 11 above (1.0 eq) in MeOH and water was added KOH (1.5 eq) at room temperature and stirred for 5 hrs. Water was added to the reaction mixture and the organic layer was separated, dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford crude product, which, on purification by column chromatography afforded the desired N-(4-amino-3-nitrophenyl)-N,N-dimethylamine. (Yield=65%).

후처리

  1. customthe organic layer was separated
  2. dry with materialdried over anhydrous Na2SO4
  3. concentrationconcentrated under reduced pressure
  4. customto afford crude product, which
  5. customon purification by column chromatography

출처 및 근거

ORD 기록
ord-c540b97dd5a64963ac6b323b56dcc6c9
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08440830B2

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