Water → 2-Bromo-3-hexylthiophene

HRID 2093121노트

반응식

HRID 2093121 반응식
[CH2:1]([C:7]1[CH:11]=[CH:10][S:9][CH:8]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[Br:12]N1C(=O)CCC1=O.O.CCCCCC>CN(C)C=O>[Br:12][C:8]1[S:9][CH:10]=[CH:11][C:7]=1[CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

참가 물질

6

반응물 4

HCID 962WaterHCID 8058HexaneHCID 67184N-bromobutanimideHCID 5668493-Hexylthiophene

생성물 1

HCID 109601412-Bromo-3-hexylthiophene수율 86.4%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

60 g of 3-n-hexylthiophene was dissolved in 400 ml of dimethylformamide, and to this, 50 g of N-bromosuccinimide was added. The resulting solution was stirred at room temperature for 4 hours under a nitrogen atmosphere. 200 ml of water and 200 ml of hexane were added to the resulting solution to separate the organic layer. The organic layer was washed with 200 ml of water and dried over magnesium sulfate, and then the solvent was distilled off under reduced pressure with a rotary evaporator to obtain 60 g of 2-bromo-3-n-hexylthiophene.

후처리

  1. customto separate the organic layer
  2. washThe organic layer was washed with 200 ml of water
  3. dry with materialdried over magnesium sulfate
  4. distillationthe solvent was distilled off under reduced pressure with a rotary evaporator

출처 및 근거

ORD 기록
ord-87118d8606004ecca0f36e94f54cf5db
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08441002B2

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