Sodium Hydroxide → 1-(5-Ethylpyridin-2-yl)ethane-1,2-diol

HRID 2094811노트

반응식

HRID 2094811 반응식
[OH-].[Na+].C([O:6][CH:7]([C:13]1[CH:18]=[CH:17][C:16]([CH2:19][CH3:20])=[CH:15][N:14]=1)[CH2:8][O:9]C(=O)C)(=O)C>O>[CH2:19]([C:16]1[CH:17]=[CH:18][C:13]([CH:7]([OH:6])[CH2:8][OH:9])=[N:14][CH:15]=1)[CH3:20]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 66823428HCID 66823428, 화합물

생성물 1

HCID 232222451-(5-Ethylpyridin-2-yl)ethane-1,2-diol

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
40 °C

실험 절차

19.91 g (0.497 mol) Sodium hydroxide was added to a solution of 71 g (0.226 mol) acetic acid 2-acetoxy-2-(5-ethyl-pyridin-2-yl)-ethyl ester in 355 mL water. Reaction mixture was stirred at 40° C. for 2 hr. After completion of reaction on TLC, reaction mixture was neutralized with con. HCl and precipitated solid was filtered off and dried to get 1-(5-ethyl-pyridin-2-yl)-ethan-1,2-diol. Yield of the product was 32.1 g (68%).

후처리

  1. customReaction mixture
  2. customAfter completion of reaction
  3. customon TLC, reaction mixture
  4. customHCl and precipitated solid
  5. filtrationwas filtered off
  6. customdried

출처 및 근거

ORD 기록
ord-49f67d39772e4d40a79c0851ad95b390
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08445685B2

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