Water → HCID 10845513, 화합물

HRID 2095274노트

반응식

HRID 2095274 반응식
C[Si](C)(C)[N-][Si](C)(C)C.[Li+].[Br:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[C:18]#[CH:19].[CH3:20]OS(OC)(=O)=O.O>O1CCCC1>[Br:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[C:18]#[C:19][CH3:20]

참가 물질

6

반응물 4

HCID 962WaterHCID 6497Dimethyl SulfateHCID 6020671-Bromo-2-ethynylbenzeneHCID 2733832Lithium Hexamethyldisilazide

생성물 1

HCID 10845513HCID 10845513, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

1M Lithium hexamethyldisilazide solution (6 mL) was added to 1-bromo-2-ethynylbenzene (1 g) in 20 mL tetrahydrofuran at room temperature, and the reaction was stirred 30 minutes. (CH3)2SO4 (0.58 mL) was added and the reaction was stirred 30 minutes. The reaction was poured into 20 mL water, extracted with 2×50 mL ether, and the combined organic layers were dried over Na2SO4, filtered, and the filtrate was concentrated.

후처리

  1. stirringthe reaction was stirred 30 minutes
  2. extractionextracted with 2×50 mL ether
  3. dry with materialthe combined organic layers were dried over Na2SO4
  4. filtrationfiltered
  5. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-214b989ff8ab47cca24132ac31c32c2c
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08445679B2

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