Trifluoroacetic acid → HCID 178506065, 화합물
반응식
[Br:1][C:2]1[N:6](S(N(C)C)(=O)=O)[N:5]=[C:4]([C:13]([F:16])([F:15])[F:14])[CH:3]=1.FC(F)(F)C(O)=O>O.[OH-].[Na+]>[Br:1][C:2]1[NH:6][N:5]=[C:4]([C:13]([F:16])([F:15])[F:14])[CH:3]=1참가 물질
5
실험 절차
A solution of 5-bromo-N,N-dimethyl-3-(trifluoromethyl)-1H-pyrazole-1-sulfonamide (i.e. the product of Example 11, Step A) (4.50 g, 14.0 mmol) and trifluoroacetic acid (2.0 mL, 26 mmol) was stirred at 25° C. for 4 h. The reaction mixture was diluted with water (20 mL), and sodium hydroxide was added to raise the pH to 12. The solution was extracted with chloroform, dried (MgSO4), and concentrated under reduced pressure to give 2.73 g of the title compound as a yellow light oil. This compound was of sufficient purity to use in subsequent reactions.
후처리
- additionwas added
- temperatureto raise the pH to 12
- extractionThe solution was extracted with chloroform
- dry with materialdried (MgSO4)
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-831f64ec4bd24200950e9b0010d4c1a3
- 출처 데이터셋
- uspto-grants-2013_05
- 특허 번호
- US08449898B2
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