Sodium Hydroxide → Sodium 1-benzylpiperidine-4-carboxylate

HRID 2096326

반응식

HRID 2096326 반응식
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]([O:16]CC)=[O:15])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+:20]>C(O)C>[CH2:1]([N:8]1[CH2:9][CH2:10][CH:11]([C:14]([O-:16])=[O:15])[CH2:12][CH2:13]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1.[Na+:20]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 90423Ethyl 1-benzylpiperidine-4-carboxylate

생성물 1

HCID 67360726Sodium 1-benzylpiperidine-4-carboxylate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution consisting of ethyl 1-benzylpiperidine-4-carboxylate (500 mg, 2.02 mmol) in ethanol (10 mL) was added 1 N sodium hydroxide (2.02 mL, 2.02 mmol) and the reaction mixture was stirred at room temperature overnight. Most of the ethanol was removed under reduced pressure and stirring was continued for six hours. Toluene was added to remove most of the water by azeotrope and the material was dried under high vacuum overnight to provide the title intermediate as a white solid.

후처리

  1. customMost of the ethanol was removed under reduced pressure
  2. stirringstirring
  3. waitwas continued for six hours
  4. additionToluene was added
  5. customto remove most of the water by azeotrope
  6. customthe material was dried under high vacuum overnight

출처 및 근거

ORD 기록
ord-477bf5fb93b9465aaa0fe72d85a82d66
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08450326B2

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