Tetramethylammonium fluoride → HCID 66697236, 화합물

HRID 2096764노트

반응식

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:23])[C:9]([C:11]2[C:20]3[O:19][CH2:18][C:17](=[O:21])[N:16]([CH3:22])[C:15]=3[CH:14]=[CH:13][CH:12]=2)=[O:10])=[C:4]([Cl:24])[CH:3]=1.[F:25][C:26]([Si](C)(C)C)([F:28])[F:27].[F-].C[N+](C)(C)C>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:23])[C:9]([C:11]2[C:20]3[O:19][CH2:18][C:17](=[O:21])[N:16]([CH3:22])[C:15]=3[CH:14]=[CH:13][CH:12]=2)([OH:10])[C:26]([F:28])([F:27])[F:25])=[C:4]([Cl:24])[CH:3]=1

참가 물질

반응물 3

HCID 67803Tetramethylammonium fluoride

HCID 552549(Trifluoromethyl)trimethylsilane

HCID 66697356HCID 66697356, 화합물

생성물 1

HCID 66697236HCID 66697236, 화합물

실험 절차

In analogy to Example 1, step 3, 8-[2-(4-bromo-2-chloro-phenyl)-propionyl]-4-methyl-4H-benzo[1,4]oxazin-3-one was reacted with (trifluoromethyl)trimethylsilane and tetramethylammonium fluoride to give the title compound as a colorless foam. MS (m/e, ISP neg. ion)=476 [M−H+].

출처 및 근거

ORD 기록: ord-4624cbafd81242ef9fcd748c8cb4bfa7
출처 데이터셋: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08450313B2

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