Hydrazine hydrate (1:1) → Pyridine, 2-hydrazinyl-3-iodo-

HRID 2096982노트

반응식

HRID 2096982 반응식
O.[NH2:2][NH2:3].F[C:5]1[C:10]([I:11])=[CH:9][CH:8]=[CH:7][N:6]=1>C(O)C>[NH:2]([C:5]1[C:10]([I:11])=[CH:9][CH:8]=[CH:7][N:6]=1)[NH2:3]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 70095012-Fluoro-3-iodopyridine

생성물 1

HCID 53402765Pyridine, 2-hydrazinyl-3-iodo-수율 46%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Hydrazine hydrate (12.50 mL, 256 mmol) was added dropwise to a solution of 2-fluoro-3-iodopyridine (preparation 26a, 5.72 g, 25.7 mmol) in ethanol (43 mL) and the resulting mixture was stirred at room temperature for 24 hours and then at 35° C. for a further 24 hours. The solvent was then evaporated in vacuo and water was added. The white solid that formed was filtered, washed with water and dried to yield the title compound (2.78 g, 46%) as a white solid which was used without further purification.

후처리

  1. waitat 35° C. for a further 24 hours
  2. customThe solvent was then evaporated in vacuo and water
  3. additionwas added
  4. customThe white solid that formed
  5. filtrationwas filtered
  6. washwashed with water
  7. customdried

출처 및 근거

ORD 기록
ord-a0ca4898366e42b3adf9538e66b721b8
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08450341B2

반응 노트

불러오는 중…