Sodium borohydride → HCID 58941864, 화합물

HRID 2097636노트

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HRID 2097636 반응식
[CH:1]([C:3]1[S:7][N:6]=[N:5][C:4]=1[C:8]([O:10][CH3:11])=[O:9])=[O:2].[BH4-].[Na+]>C(O)C>[OH:2][CH2:1][C:3]1[S:7][N:6]=[N:5][C:4]=1[C:8]([O:10][CH3:11])=[O:9]

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 14913987Methyl 5-formyl-1,2,3-thiadiazole-4-carboxylate

생성물 1

HCID 58941864HCID 58941864, 화합물수율 75.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Methyl 5-formyl-1,2,3-thiadiazole-4-carboxylate (460.0 mg, 0.0026 mol) was dissolved in ethanol (40 mL) and sodium tetrahydroborate (50 mg, 0.0013 mol) was added at 0° C. The orange solution was allowed to warm to room temp and was stirred for 30 minutes. The reaction was quenched with acetic acid and then purified by preparative LCMS to give the desired product (340 mg, 73%). MF═C5H6N2O3S; LCMS calculated for C5H7N2O3S(M+H)+: m/z=175.1.

후처리

  1. customThe reaction was quenched with acetic acid
  2. custompurified by preparative LCMS

출처 및 근거

ORD 기록
ord-32acbc96fdb5443c97feed86e78f51d5
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08450351B2

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