N-bromobutanimide → 5-Fluoro-2-iodo-4-trifluoromethyl-phenylamine

HRID 2098106노트

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HRID 2098106 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[C:9]([F:12])([F:11])[F:10])[NH2:5].C1C(=O)N([Br:20])C(=O)C1>C(Cl)Cl>[Br:20][C:6]1[CH:7]=[C:8]([C:9]([F:10])([F:11])[F:12])[C:2]([F:1])=[CH:3][C:4]=1[NH2:5]

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 27359144-Amino-2-fluorobenzotrifluoride

생성물 1

HCID 687591875-Fluoro-2-iodo-4-trifluoromethyl-phenylamine

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a stirring mixture of 3-fluoro-4-(trifluoromethyl)aniline (1.5 g) in DCM (12 mL) at room temperature was added dropwise a solution of NBS (1.5 g) in DCM (24 mL) over 15 min. The reaction mixture was stirred at rt for 1.5 h. The product mixture was concentrated under reduced pressure to one half of its original volumn. The white solid was filtered off and the crude product mixture was further purified via column chromatography. Retention time (min)=2.490, method [1], MS (ESI) 257.9 (M+H).

후처리

  1. concentrationThe product mixture was concentrated under reduced pressure to one half of its original volumn
  2. filtrationThe white solid was filtered off
  3. customthe crude product mixture was further purified via column chromatography

출처 및 근거

ORD 기록
ord-3abb1aa54f554404833c0b7198a05abd
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08450363B2

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