HCID 86649425, 화합물 → 7-Fluoro-6-(trifluoromethyl)-2(1H)-quinolinone

HRID 2098108노트

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HRID 2098108 반응식
[NH2:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([C:9]([F:12])([F:11])[F:10])=[CH:4][C:3]=1/[CH:13]=[CH:14]/[C:15]([O:17]CC)=O>Cl.O1CCOCC1>[F:8][C:6]1[CH:7]=[C:2]2[C:3]([CH:13]=[CH:14][C:15](=[O:17])[NH:1]2)=[CH:4][C:5]=1[C:9]([F:12])([F:11])[F:10]

참가 물질

4

반응물 1

HCID 86649425HCID 86649425, 화합물

생성물 1

HCID 687838897-Fluoro-6-(trifluoromethyl)-2(1H)-quinolinone

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매2회HCID 312751,4-Dioxane용매

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온도
100 °C

실험 절차

To a stirring mixture of (E)-ethyl 3-(2-amino-4-fluoro-5-(trifluoromethyl)phenyl)acrylate in 4N HCl in dioxane (10 mL) was added concentrated HCl (2 mL). The resulting mixture was warmed to 100° C. overnight. The reaction mixture was cooled to rt and then slowly quenched with a cold saturated NaHCO3 solution until pH>7. A normal aqueous extraction with EtOAc was followed. The crude mixture was taken directly to the next reaction without further purification. Retention time (min)=1.887, method [1], MS (ESI) 232.0 (M+H).

후처리

  1. temperatureThe reaction mixture was cooled to rt
  2. customslowly quenched with a cold saturated NaHCO3 solution until pH>7
  3. extractionA normal aqueous extraction with EtOAc
  4. customThe crude mixture was taken directly to the next reaction without further purification

출처 및 근거

ORD 기록
ord-8a82077600eb4b85849b28e421274027
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08450363B2

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