37441-16-0 → HCID 44128653, 화합물

HRID 2098303노트

반응식

HRID 2098303 반응식
[N:1]([CH2:4][CH2:5][S:6][CH3:7])=[C:2]=[O:3].[N+:8](=[C:10]1[N:14]=[CH:13][N:12]=[C:11]1[C:15]([NH2:17])=[O:16])=[N-:9]>CS(C)=O>[CH3:7][S:6][CH2:5][CH2:4][N:1]1[C:2](=[O:3])[N:14]2[CH:13]=[N:12][C:11]([C:15]([NH2:17])=[O:16])=[C:10]2[N:8]=[N:9]1

참가 물질

4

반응물 2

HCID 1787232937441-16-0HCID 534265854-Diazo-4H-imidazole-5-carboxamide

생성물 1

HCID 44128653HCID 44128653, 화합물

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

1-Isocyanato-2-methylsulfanyl-ethane (1.09 g, 9.31 mmol) was added drop wise to a suspension of 5-diazoimidazole-4-carboxamide (0.5 g, 3.65 mmol) in dry dimethylsulfoxide (5 mL) at room temperature under nitrogen. The resulting mixture was stirred at room temperature overnight. The reaction was quenched by the addition of ice and the solid product (brown) was removed by filtration, washed with Et2O, and purified using flash chromatography (SiO2) using MeCN:CH2Cl2 (0-100% MeCN) Yield: 52 mg, 26%. 1H NMR (400 MHz, d6-DMSO) δ ppm: 8.87 (1H, s), 7.80 (1H, s), 7.66 (1H, s), 4.48 (2H, t), 2.94 (2H, t).

후처리

  1. customThe reaction was quenched by the addition of ice
  2. customthe solid product (brown) was removed by filtration
  3. washwashed with Et2O
  4. custompurified

출처 및 근거

ORD 기록
ord-8be1f7dbadd54db2b4922f226690c6d1
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08450479B2

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