Water → 5-Cyano-2,3'-bipyridine-6'-carboxylic acid
반응식
[C:1]([C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:10]=[N:11][C:12]([C:15]([O:17]C)=[O:16])=[CH:13][CH:14]=2)=[N:7][CH:8]=1)#[N:2].O.[Li+].[OH-]>O1CCCC1>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:10]=[N:11][C:12]([C:15]([OH:17])=[O:16])=[CH:13][CH:14]=2)=[N:7][CH:8]=1)#[N:2]참가 물질
5
실험 절차
To a 250 ml flask was added methyl 5-cyano-2,3′-bipyridine-6′-carboxylate (950 mg, 3.57 mmol), water (9.5 ml), tetrahydrofuran (38.4 ml) and LiOH (86 mg, 3.57 mmol). The mixture was stirred for 30 min, diluted with tetrahydrofuran (200 ml) and cooled to 0° C. (ice water batch). After an additional 30 min, the resulting suspension was filtered, washed with THF and dried under reduced pressure to afford the desired product as a light brown powder. LCMS (m/z): 226.1 (M+H).
후처리
- waitAfter an additional 30 min
- filtrationthe resulting suspension was filtered
- washwashed with THF
- customdried under reduced pressure
출처 및 근거
- ORD 기록
- ord-b999a10f9a604241b5d1d6d500c4f2a8
- 출처 데이터셋
- uspto-grants-2013_05
- 특허 번호
- US08450484B2
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