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Hydrochloric Acid → ((1,1-Dimethylethyl)oxymethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-carboxylic acid

HRID 2098954
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HRID 2098954 반응식
Br[CH2:2][C:3]1[CH:8]=[C:7]([C:9]([O:11]C)=[O:10])[CH:6]=[CH:5][C:4]=1[C:13]1[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=1[F:21].[CH3:22][C:23]([O-:26])([CH3:25])[CH3:24].[Na+].Cl>CN(C=O)C>[CH3:22][C:23]([O:26][CH2:2][C:3]1[CH:8]=[C:7]([C:9]([OH:11])=[O:10])[CH:6]=[CH:5][C:4]=1[C:13]1[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=1[F:21])([CH3:25])[CH3:24]
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참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 23676156Sodium t-butoxideHCID 57705537Methyl 2-(bromomethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-carboxylate

생성물 1

HCID 57705535((1,1-Dimethylethyl)oxymethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-carboxylic acid수율 20%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of T31.2 (0.245 g, 0.69 mmol) and sodium 2-methylpropan-2-olate (0.20 g, 2.1 mmol) in DMF (6 mL) was stirred at room temperature for 28 minutes. The mixture was acidified with 1N HCl to pH 3-4 and then was extracted with EtOAc (100 mL). The organic phase was washed with brine and dried over anhydrous Na2SO4. After removing solvent, the residue was purified by flash chromatography (silica gel, 1:4 EtOAc/hexane) and gave T31.3 (49 mg) in 20% yield.

후처리

  1. extractionwas extracted with EtOAc (100 mL)
  2. washThe organic phase was washed with brine
  3. dry with materialdried over anhydrous Na2SO4
  4. customAfter removing solvent
  5. customthe residue was purified by flash chromatography (silica gel, 1:4 EtOAc/hexane)
  6. customgave T31.3 (49 mg) in 20% yield

출처 및 근거

ORD 기록
ord-3585b274ab6849cb8536bb79e71e2a0d
출처 데이터셋
uspto-grants-2013_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08450522B2

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