Pyridine → 2(R)-acetoxycyclopent-1(R)-yl chloroformate

HRID 2099258노트

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HRID 2099258 반응식
[CH3:1][C:2]([O:4][C@H:5]1[C@H:9]([OH:10])[CH2:8][CH2:7][CH2:6]1)=[O:3].N1C=CC=CC=1.[Cl:17][C:18](Cl)([O:20]C(=O)OC(Cl)(Cl)Cl)Cl>ClCCl>[Cl:17][C:18]([O:10][C@@H:9]1[CH2:8][CH2:7][CH2:6][C@H:5]1[O:4][C:2](=[O:3])[CH3:1])=[O:20]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 94429TriphosgeneHCID 12483669(1R,2R)-2-Hydroxycyclopentyl acetate

생성물 1

HCID 865905632(R)-acetoxycyclopent-1(R)-yl chloroformate

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

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온도
0 °C

실험 절차

To a stirred solution of (1R,2R)-trans-2-acetoxy-1-cyclopentanol (1.0 g, 6.9 mmol) in dichloromethane (25 mL) at 0° C. under nitrogen atmosphere was added pyridine (0.88 mL, 10.4 mmol) followed by a solution of triphosgene (1.03 g, 3.5 mmol) in dichloromethane (25 mL). The reaction mixture was stirred at 0° C. for 30 min. to provide the corresponding 2(R)-acetoxycyclopent-1(R)-yl chloroformate which was carried to next step without further purification.

출처 및 근거

ORD 기록
ord-6a3db3481e4542c08cf1bc1b118cbbea
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07569576B2

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