N-bromobutanimide → 4-amino-7-bromo-2,3-dihydro-1H-isoindole-1,3-dione

HRID 20993

반응식

HRID 20993 반응식
[NH2:1][C:2]1[CH:12]=[CH:11][CH:10]=[C:4]2[C:5]([NH:7][C:8](=[O:9])[C:3]=12)=[O:6].[Br:13]N1C(=O)CCC1=O>CO>[NH2:1][C:2]1[CH:12]=[CH:11][C:10]([Br:13])=[C:4]2[C:5]([NH:7][C:8](=[O:9])[C:3]=12)=[O:6]

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 729141H-Isoindole-1,3(2H)-dione, 4-amino-

생성물 1

HCID 684890894-amino-7-bromo-2,3-dihydro-1H-isoindole-1,3-dione수율 74.5%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

3-Aminophthalimide (2.00 g, 12.3 mmol) was dissolved in methanol (200 mL), and the solution was added with N-bromosuccinimide (2.19 g, 12.3 mmol), followed by stirring at room temperature for 50 minutes. The obtained solid was collected by filtration and washed with methanol to obtain 3-amino-6-bromophthalimide (2.21 g, yield 74%).

후처리

  1. filtrationThe obtained solid was collected by filtration
  2. washwashed with methanol

출처 및 근거

ORD 기록
ord-71a5479c3a334ee98e9d5b229fda0e3e
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745641B2

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