HCID 68828337, 화합물 → HCID 11570771, 화합물

HRID 2099352노트

반응식

HRID 2099352 반응식
[Cl:1][C:2]1[CH:47]=[CH:46][C:5]([CH2:6][C@@H:7]([NH:32][CH:33]2[CH2:38][CH2:37][N:36](C(OC(C)(C)C)=O)[CH2:35][CH2:34]2)[C:8]([N:10]2[CH:15]3[CH2:16][CH2:17][CH:11]2[CH2:12][CH:13]([N:18]([CH:26]2[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]2)[C:19]([N:21]([CH2:24][CH3:25])[CH2:22][CH3:23])=[O:20])[CH2:14]3)=[O:9])=[CH:4][CH:3]=1>Cl.C(OCC)C>[ClH:1].[Cl:1][C:2]1[CH:47]=[CH:46][C:5]([CH2:6][C@H:7]([C:8]([N:10]2[CH:15]3[CH2:16][CH2:17][CH:11]2[CH2:12][CH:13]([N:18]([CH:26]2[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31]2)[C:19]([N:21]([CH2:22][CH3:23])[CH2:24][CH3:25])=[O:20])[CH2:14]3)=[O:9])[NH:32][CH:33]2[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]2)=[CH:4][CH:3]=1

참가 물질

4

반응물 1

HCID 68828337HCID 68828337, 화합물

생성물 1

HCID 11570771HCID 11570771, 화합물수율 161.2%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 3283Diethyl Ether용매

실험 절차

0.37 g of tert-butyl 4-{[(1R)-1-(4-chlorobenzyl)-2-(3-{cyclohexyl[(diethylamino)carbonyl]amino}-8-azabicyclo[3.2.1]oct-8-yl)-2-oxoethyl]amino}-piperidine-1-carboxylate is solubilized in 2.74 ml of 2N hydrochloric acid in diethyl ether. The reaction medium is stirred at ambient temperature for 16 h. After evaporation to dryness, the crude is chromatographed on silica gel, elution being carried out with a 95/5/0.5 mixture of dichloromethane, methanol and aqueous ammonia. 0.27 g of N-[8-(4-chloro-N-piperidin-4-yl-D-phenylalanyl)-8-azabicyclo-[3.2.1]oct-3-yl]-N-cyclohexyl-N′,N′-diethylurea hydrochloride is then obtained.

후처리

  1. customAfter evaporation to dryness
  2. customthe crude is chromatographed on silica gel, elution
  3. additionbeing carried out with a 95/5/0.5 mixture of dichloromethane, methanol and aqueous ammonia

출처 및 근거

ORD 기록
ord-8ea7520a4b1e4b03afd66ce1733249df
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07569582B2

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