Hydrogen Bromide → 4-(2-(Ethylamino)propyl)-1,2-benzenediol hydrobromide

HRID 2099709

반응식

HRID 2099709 반응식
C[O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH:12]([NH:14][CH2:15][CH3:16])[CH3:13])[CH:6]=[CH:7][C:8]=1[O:9]C.[BrH:17]>>[BrH:17].[CH2:15]([NH:14][CH:12]([CH3:13])[CH2:11][C:5]1[CH:4]=[C:3]([OH:2])[C:8]([OH:9])=[CH:7][CH:6]=1)[CH3:16]

참가 물질

3

반응물 2

HCID 260Hydrogen BromideHCID 22061570[2-(3,4-Dimethoxy-phenyl)-1-methyl-ethyl]-ethyl amine

생성물 1

HCID 1303564-(2-(Ethylamino)propyl)-1,2-benzenediol hydrobromide

실험 절차

A solution of 1.1 g (4.92 mmol) of 2A in 10 mL of 48% HBr was heated to reflux under argon atmosphere for 3.5 hours and then concentrated to dryness under reduced pressure. To this was added 50 mL of dichloromethane and concentrated to dryness under reduced pressure to give crude 2B as a dark brown powder (M+Na, 318).

후처리

  1. temperatureto reflux under argon atmosphere for 3.5 hours
  2. concentrationconcentrated to dryness under reduced pressure
  3. additionTo this was added 50 mL of dichloromethane
  4. concentrationconcentrated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-1b9609bfe6814631b914b313d1b6d23a
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07569676B2

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