Tetramethylammonium hydroxide → (2alpha,3alpha,5alpha,16beta,17beta)-2,3-Epoxy-16-(1-pyrrolidinyl)androstan-17-ol

HRID 2099865

반응식

HRID 2099865 반응식
CC([O:4][C@@H:5]1[C@@:9]2([CH3:30])[CH2:10][CH2:11][C@@H:12]3[C@@:17]4([CH3:29])[CH2:18][C@H:19](N5CCOCC5)[C@@H:20]([OH:22])[CH2:21][C@@H:16]4[CH2:15][CH2:14][C@H:13]3[C@@H:8]2[CH2:7][C@@H:6]1[N+:31]1(CC=C)[CH2:35][CH2:34][CH2:33][CH2:32]1)=O.[Br-].[OH-].C[N+](C)(C)C>C(#N)C>[O:22]1[C@H:20]2[CH2:19][C@H:18]3[C@:17]([CH3:29])([CH2:16][C@@H:21]12)[C@@H:12]1[C@H:13]([C@H:8]2[C@@:9]([CH2:10][CH2:11]1)([CH3:30])[C@@H:5]([OH:4])[C@@H:6]([N:31]1[CH2:35][CH2:34][CH2:33][CH2:32]1)[CH2:7]2)[CH2:14][CH2:15]3

참가 물질

4

반응물 2

HCID 60966Tetramethylammonium hydroxideHCID 441351Rocuronium Bromide

생성물 1

HCID 16063872(2alpha,3alpha,5alpha,16beta,17beta)-2,3-Epoxy-16-(1-pyrrolidinyl)androstan-17-ol

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Analysis of rocuronium bromide, Compound I, was performed with a column & packing Hypersil silica; 5 μm, 250 mm×4.6 mm, Cat No. 30005-254630 or equivalent. Eluent A was tetramethylammonium hydroxide Buffer, 0.05M, pH 7.4, eluent B was acetonitrile, and the composition was 10:90, A:B. The stop time was 25 min., the flow rate was 2.0 mL/min., the detector was UV at 210 mn, the column temperature was 30° C., and the injection volume was 5 μl.

후처리

  1. customwas 30° C.

출처 및 근거

ORD 기록
ord-2b69b775bba2444685f16f95aed32433
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07569687B2

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