Hydrochloric Acid → 3-(4-Fluoro-3-methoxyphenyl)prop-2-enoic acid
반응식
[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][C:3]=1[O:10][CH3:11].C(O)(=O)[CH2:13][C:14]([OH:16])=[O:15].Cl>N1C=CC=CC=1.N1CCCCC1>[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[CH:13][C:14]([OH:16])=[O:15])=[CH:4][C:3]=1[O:10][CH3:11]참가 물질
6
반응 조건
- 온도
- 120 °C
실험 절차
A mixture of 4-Fluoro-3-methoxy-benzaldehyde (6.16 g, 40 mmol), and malonic acid (6.24 g, 60 mmol) in pyridine (30 ml) and piperidine (1 ml) was heated at 120° C. for 2 hrs. The mixture was cooled to room temperature and neutralized with concentrated HCl to PH<3, the white solid was collected and dried to give 7.6 g of product (97% yield). LC-MS: m/e 195 (M−1)
후처리
- customthe white solid was collected
- customdried
출처 및 근거
- ORD 기록
- ord-7c2cf292a17f448dae2c111e5cf6b23e
- 출처 데이터셋
- uspto-grants-2009_08
- 특허 번호
- US07572809B2
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