Lithium hydroxide, monohydrate → 2,3-Dihydro-6-methoxy-3-oxo-1H-indene-5-carboxylic acid

HRID 2100750노트

반응식

HRID 2100750 반응식
C[O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][C:13]=1[O:14][CH3:15])[CH2:10][CH2:9][C:8]2=[O:16])=[O:4].O[Li].O>C1COCC1.O>[CH3:15][O:14][C:13]1[CH:12]=[C:11]2[C:7]([C:8](=[O:16])[CH2:9][CH2:10]2)=[CH:6][C:5]=1[C:3]([OH:4])=[O:2]

참가 물질

5

반응물 2

HCID 168937Lithium hydroxide, monohydrateHCID 57799525HCID 57799525, 화합물

생성물 1

HCID 537374072,3-Dihydro-6-methoxy-3-oxo-1H-indene-5-carboxylic acid수율 90.2%

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

6-Methoxy-3-oxo-indan-5-carboxylic acid methyl ester (4 g, 18.18 mmol) was added to a solution of LiOH.H2O (2.2 g, 54.5 mmol) in THF (40 ml) and H2O (40 ml), then the mixture was heated to reflux and stirred for one hour. After removal of THF, the residue was acidified to PH=3, and the precipitate was collected and dried to give a white solid (3.38 g, 89.8%). LC-MS: m/e 207 (MH+)

후처리

  1. temperaturethe mixture was heated
  2. temperatureto reflux
  3. customAfter removal of THF
  4. customthe precipitate was collected
  5. customdried

출처 및 근거

ORD 기록
ord-5dd27c492fec41a382126e7032e88c80
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07572809B2

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