Phosphorus oxychloride → (1,5-Dichloro-6,7-dimethoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine

HRID 2101139노트

반응식

HRID 2101139 반응식
[Cl:1][C:2]1[C:11]([O:12][CH3:13])=[C:10]([O:14][CH3:15])[CH:9]=[C:8]2[C:3]=1[CH:4]=[C:5]([NH:17][C:18]1[CH:22]=[C:21]([CH3:23])[NH:20][N:19]=1)[N:6]=[C:7]2O.O=P(Cl)(Cl)[Cl:26]>>[Cl:26][C:7]1[C:8]2[C:3](=[C:2]([Cl:1])[C:11]([O:12][CH3:13])=[C:10]([O:14][CH3:15])[CH:9]=2)[CH:4]=[C:5]([NH:17][C:18]2[CH:22]=[C:21]([CH3:23])[NH:20][N:19]=2)[N:6]=1

참가 물질

3

반응물 2

HCID 24813Phosphorus oxychlorideHCID 178486774HCID 178486774, 화합물

생성물 1

HCID 57799846(1,5-Dichloro-6,7-dimethoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine

실험 절차

Similar procedure as described in example 9B was used, starting from 5-Chloro-6,7-dimethoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-ol and POCl3 to give (1,5-Dichloro-6,7-dimethoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine. LC-MS: m/e 353 (MH+).

출처 및 근거

ORD 기록
ord-2db035b96da2439fb06216ac1e0233f6
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07572809B2

반응 노트

불러오는 중…