Methanol → 3-(4-Methoxyphenyl)-1-phenylprop-2-en-1-one

HRID 2101224

반응식

HRID 2101224 반응식
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[OH-].[Na+].CO.[CH:14](=O)[C:15]1[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=1>C(OC(=O)C)C>[CH3:22][O:21][C:18]1[CH:19]=[CH:20][C:15]([CH:14]=[CH:2][C:1]([C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)=[O:3])=[CH:16][CH:17]=1

참가 물질

6

반응물 4

HCID 887MethanolHCID 7410AcetophenoneHCID 14798Sodium HydroxideHCID 312444-Methoxybenzaldehyde

생성물 1

HCID 941973-(4-Methoxyphenyl)-1-phenylprop-2-en-1-one

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Acetophenone (0.5 g) and sodium hydroxide (0.17 g) were suspended in 15 Ml of methanol pre-chilled at −10° C. p-Anisaldehyde (0.57 g) was added thereto, and stirred for 10 hr at room temperature. After neutralization with 5% hydrochloric acid solution, the product was extracted with 100 Ml of ethylacetate. The extracted organic phase was dried with anhydrous magnesium sulfate, and concentrated under vacuum evaporator. Purified compound was obtained by elution with n-hexane:ethylacetate (v/v, 1:7) through silica gel column chromatography (5×3 cm, Merk), and identified as follows:

후처리

  1. additionwas added
  2. extractionAfter neutralization with 5% hydrochloric acid solution, the product was extracted with 100 Ml of ethylacetate
  3. dry with materialThe extracted organic phase was dried with anhydrous magnesium sulfate
  4. concentrationconcentrated under vacuum evaporator
  5. customPurified compound was obtained by elution with n-hexane

출처 및 근거

ORD 기록
ord-6be23af2371049c49a375372ad07cdd3
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07572831B2

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