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Hydrochloric Acid → 2-benzyl-3-[1-(3,5-dichloro-benzyl)-1H-imidazol-2-yl]-propionic acid

HRID 2101501
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인쇄 미리보기

반응식

HRID 2101501 반응식
C([O:3][C:4](=[O:28])[CH:5]([CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[CH2:6][C:7]1[N:8]([CH2:12][C:13]2[CH:18]=[C:17]([Cl:19])[CH:16]=[C:15]([Cl:20])[CH:14]=2)[CH:9]=[CH:10][N:11]=1)C.Cl>C1COCC1>[CH2:21]([CH:5]([CH2:6][C:7]1[N:8]([CH2:12][C:13]2[CH:18]=[C:17]([Cl:19])[CH:16]=[C:15]([Cl:20])[CH:14]=2)[CH:9]=[CH:10][N:11]=1)[C:4]([OH:28])=[O:3])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1
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참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 119553452-benzyl-3-[1-(3,5-dichloro-benzyl)-1H-imidazol-2-yl]-propionic acid ethyl ester

생성물 1

HCID 119524852-benzyl-3-[1-(3,5-dichloro-benzyl)-1H-imidazol-2-yl]-propionic acid수율 84%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
75 °C

실험 절차

To a solution of 2-benzyl-3-[1-(3,5-dichloro-benzyl)-1H-imidazol-2-yl]-propionic acid ethyl ester (50 mg, 0.12 mmol) in THF (3 mL) was added 6 N HCl (3 mL). The mixture was heated at 75° C. for 14 h with vigorous stirring. The reaction was concentrated in vacuo and the residue washed with Et2O then dried in vacuo to provide the hydrochloride salt of 2-benzyl-3-[1-(3,5-dichloro-benzyl)-1H-imidazol-2-yl]-propionic acid (26 mg, 84%) as a white solid: ESI MS m/z 389 [C20H18Cl2N2O2+H]+.

후처리

  1. concentrationThe reaction was concentrated in vacuo
  2. washthe residue washed with Et2O
  3. customthen dried in vacuo

출처 및 근거

ORD 기록
ord-946d3019dd144c49a7327ddda7dacc0b
출처 데이터셋
uspto-grants-2009_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07572921B2

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