Hydrochloric Acid → 4-(Morpholin-4-ylcarbonyl)piperidine-4-carbonitrile hydrochloride

HRID 2102388노트

반응식

HRID 2102388 반응식
[C:1]([C:3]1([C:16]([N:18]2[CH2:23][CH2:22][O:21][CH2:20][CH2:19]2)=[O:17])[CH2:8][CH2:7][N:6](C(OC(C)(C)C)=O)[CH2:5][CH2:4]1)#[N:2].[ClH:24]>O1CCOCC1>[ClH:24].[N:18]1([C:16]([C:3]2([C:1]#[N:2])[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]2)=[O:17])[CH2:19][CH2:20][O:21][CH2:22][CH2:23]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 57803090tert-Butyl 4-cyano-4-(morpholin-4-ylcarbonyl)piperidine-1-carboxylate

생성물 1

HCID 688129634-(Morpholin-4-ylcarbonyl)piperidine-4-carbonitrile hydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To tert-Butyl 4-cyano-4-(morpholin-4-ylcarbonyl)piperidine-1-carboxylate (I-2) (11.95 g, 40 mmole) was added 4M HCl in dioxane (80 mL). The resulting reaction mixture was stirred for 1 h at room temperature. After this time, LCMS indicated that the reaction was complete. The reaction was concentrated to afford the title compound (I-3) as a white solid. This product was pure enough for next step reaction. Analytical LCMS: single peak (214 nm), 0.548 min.

후처리

  1. customThe resulting reaction mixture
  2. concentrationThe reaction was concentrated

출처 및 근거

ORD 기록
ord-f434f6f21dcd4d3dafd833277de7a7cd
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07576083B2

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