Sodium Hydroxide → 2-(Hydroxymethyl)-4-(trifluoromethyl)pyridine
반응식
C([O:4][CH2:5][C:6]1[CH:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:9]=[CH:8][N:7]=1)(=O)C.[OH-].[Na+]>CO.O>[F:14][C:12]([F:13])([F:15])[C:10]1[CH:9]=[CH:8][N:7]=[C:6]([CH2:5][OH:4])[CH:11]=1참가 물질
5
실험 절차
To a solution of [4-(trifluoromethyl)pyridin-2-yl]methyl acetate (1.0 g, 3.2 mmol) in methanol (10 mL) was added a 1.0 M solution of sodium hydroxide in water (10 mL). After being stirred at room temperature overnight, the solution was diluted with 20 mL of water and extracted with EtOAc twice. The combined organic layers were dried (MgSO4) and concentrated under vacuum. Chromatography on silica gel eluting with hexanes/EtOAc (1:1) afforded the title compound (0.34 g) as a clear oil. MS (M+H) 178.1.
후처리
- extractionextracted with EtOAc twice
- dry with materialThe combined organic layers were dried (MgSO4)
- concentrationconcentrated under vacuum
출처 및 근거
- ORD 기록
- ord-0c404cfbe6894741a43fa89890001780
- 출처 데이터셋
- uspto-grants-2009_08
- 특허 번호
- US07576089B2
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