Sodium Chloride → N,N-Dimethyl-N'-(5-bromothiophene-2-sulfonyl)formamidine

HRID 2103615노트

반응식

HRID 2103615 반응식
CO[CH:3]([N:6]([CH3:8])[CH3:7])OC.[Br:9][C:10]1[S:14][C:13]([S:15]([NH2:18])(=[O:17])=[O:16])=[CH:12][CH:11]=1.[Cl-].[Na+]>CN(C=O)C>[CH3:7][N:6]([CH:3]=[N:18][S:15]([C:13]1[S:14][C:10]([Br:9])=[CH:11][CH:12]=1)(=[O:17])=[O:16])[CH3:8]

참가 물질

5

반응물 3

HCID 5234Sodium ChlorideHCID 78373Dimethylformamide dimethyl acetalHCID 12413045-Bromo-2-thiophenesulfonamide

생성물 1

HCID 54319951N,N-Dimethyl-N'-(5-bromothiophene-2-sulfonyl)formamidine수율 114.1%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Add dimethoxymethyl-dimethyl-amine (1.05 mL, 7.66 mmol) to a solution-of 5-bromo-thiophene-2-sulfonic acid amide (1.8 g, 7.43 mmol) in DMF (3 mL) at r.t. for 16 h. Pour reaction mixture into saturated sodium chloride, extract with ethylacetate. Wash combined organic layers with water, dry over sodium sulfate and remove solvent to obtain 2.52 g product. MS (m/e): 297.0/299.0 (M+H).

후처리

  1. additionPour
  2. extractionextract with ethylacetate
  3. washWash
  4. dry with materialdry over sodium sulfate
  5. customremove solvent

출처 및 근거

ORD 기록
ord-c03efdef1d594c498a5dc8be1f6972cb
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07576108B2

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