Hydrogen Bromide → 3-(4-Bromo-phenylsulfanylmethyl)-pyridine

HRID 2103634노트

반응식

HRID 2103634 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([SH:8])=[CH:4][CH:3]=1.Br.Br[CH2:11][C:12]1[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:11][C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 260Hydrogen BromideHCID 11430Potassium CarbonateHCID 660494-BromothiophenolHCID 2459343-(Bromomethyl)pyridine

생성물 1

HCID 130587393-(4-Bromo-phenylsulfanylmethyl)-pyridine수율 85.9%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

Following method of example 9a, reaction of 4-bromo-benzenethiol (4.8 g, 24.1 mmol) with hydrobromic acid salt of 3-bromomethyl-pyridine (6.9 g, 26.5 mmol) and potassium carbonate (7.3 g, 53 mmol) in 91 ml acetone gives the title compound as a yellow solid (5.8 g). MS (m/e): 281 (M+H).

출처 및 근거

ORD 기록
ord-70303cb3f2fd4795b0afacdd68d096d4
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07576108B2

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