Hydrochloric Acid → Hydrochloric Acid

HRID 2104236노트

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HRID 2104236 반응식
C(OC([N:8]1[CH2:13][CH2:12][C:11]([C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([O:22][CH3:23])[CH:16]=2)([OH:14])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>CO.CCOCC>[Cl:21][C:18]1[CH:19]=[CH:20][C:15]([C:11]2([OH:14])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[CH:16][C:17]=1[O:22][CH3:23].[ClH:24]

참가 물질

6

반응물 2

HCID 313Hydrochloric AcidHCID 68503586HCID 68503586, 화합물

생성물 2

HCID 313Hydrochloric AcidHCID 578055554-(4-Chloro-3-methoxyphenyl)-4-piperidinol

시약·촉매·용매 2

HCID 887Methanol용매HCID 3283Diethyl Ether용매2회

반응 조건

온도
0 °C

실험 절차

To a solution of 4-(4-Chloro-3-methoxy-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester (502 mg) in MeOH (5 mL) was added a solution of HCl in ether (2 M, 9.5 mL). The resultant mixture was stirred at room temperature for 1 h followed by the addition of ether (50 mL). The reaction mixture was stirred at 0° C. for an additional 30 min, then filtered and concentrated to provide 4-(4-Chloro-3-methoxy-phenyl)-piperidin-4-ol in the form of HCl salt as a white solid.

후처리

  1. filtrationfiltered
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-5ea57e5f3c1247d9b2bf90bbbaeb9ff1
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07576218B2

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