Triethylsilane → 2-Chloro-4-ethyl-1-fluorobenzene

HRID 2105028

반응식

HRID 2105028 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:9](=O)[CH3:10])[CH:5]=[CH:6][C:7]=1[F:8].C([SiH](CC)CC)C>C(O)(C(F)(F)F)=O>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][CH3:10])[CH:5]=[CH:6][C:7]=1[F:8]

참가 물질

4

반응물 2

HCID 12052TriethylsilaneHCID 5204223'-Chloro-4'-fluoroacetophenone

생성물 1

HCID 187118782-Chloro-4-ethyl-1-fluorobenzene수율 28.3%

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

To a solution of 3′-chloro-4′-fluoroacetophenone (5.2 g, 30.1 mmol) in 30 mL TFA, was added triethylsilane (14.4 mL, 90.4 mmol). The mixture was stirred at rt for 15 h, then concentrated. The crude product was purified by flash chromatography (100% hexanes, 2×) to afford 1.35 g of Intermediate 221.1 as a colorless oil.

후처리

  1. concentrationconcentrated
  2. customThe crude product was purified by flash chromatography (100% hexanes, 2×)

출처 및 근거

ORD 기록
ord-e628bb131f7d41c080af62910a34c143
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07576098B2

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