1-Methyl-3-phenyl-1H-1,2,4-triazole → (5-ethyl-2-fluorophenyl)(2-methyl-5-phenyl-2H-1,2,4-triazol-3-yl)methanol

HRID 2105061

반응식

HRID 2105061 반응식
[CH2:1]([C:3]1[CH:4]=[C:5]([CH:9]([C:11]2[N:12]([CH3:22])[N:13]=[C:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[N:15]=2)[OH:10])[CH:6]=[CH:7][CH:8]=1)[CH3:2].CN1C=NC(C2C=CC=CC=2)=N1.C(C1C=CC([F:45])=C(C=1)C=O)C>>[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([F:45])=[C:5]([CH:9]([C:11]2[N:12]([CH3:22])[N:13]=[C:14]([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)[N:15]=2)[OH:10])[CH:4]=1)[CH3:2]

참가 물질

4

반응물 3

HCID 108774081-Methyl-3-phenyl-1H-1,2,4-triazoleHCID 57803786(3-ethylphenyl)(2-methyl-5-phenyl-2H-1,2,4-triazol-3-yl)methanolHCID 578038035-Ethyl-2-fluorobenzaldehyde

생성물 1

HCID 57803805(5-ethyl-2-fluorophenyl)(2-methyl-5-phenyl-2H-1,2,4-triazol-3-yl)methanol

실험 절차

According to the procedure for Intermediate 370.2, 1-methyl-3-phenyl-1H-1,2,4-triazole (105 mg, 0.66 mmol) and 5-ethyl-2-fluorobenzaldehyde (100 mg, 0.66 mmol) afforded 159 mg of Intermediate 385.1 as a white solid. 1H NMR (400 MHz, CDCl3) δ ppm 1.12 (t, J=7.70 Hz, 3H) 2.47 (q, J=7.42 Hz, 2H) 2.95 (d, J=9.05 Hz, 1H) 5.48 (d, J=9.29 Hz, 1H) 6.67 (dd, J=9.90, 8.44 Hz, 1H) 6.87-6.99 (m, 1H) 7.03 (dd, J=7.34, 2.20 Hz, 1H) 7.08-7.15 (m, 6H) 7.15-7.22 (m, 10H) 7.30-7.48 (m, 5H) 8.04-8.16 (m, 2H).

출처 및 근거

ORD 기록
ord-4515e50cee2547a3a88efedbf277ae9c
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07576098B2

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