Methyl iodide → Quinolinium, 1,2-dimethyl-6-nitro-, iodide

HRID 2105104노트

반응식

HRID 2105104 반응식
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:12]([O-:14])=[O:13])[CH:8]=2)[N:3]=1.[I:15][CH3:16]>C(#N)C>[I-:15].[CH3:16][N+:3]1[C:4]2[C:9](=[CH:8][C:7]([N+:12]([O-:14])=[O:13])=[CH:6][CH:5]=2)[CH:10]=[CH:11][C:2]=1[CH3:1]

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 691722-Methyl-6-nitroquinoline

생성물 1

HCID 12252537Quinolinium, 1,2-dimethyl-6-nitro-, iodide수율 16.8%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

2-Methyl-6-nitroquinoline (0.5 g, 2.66 mmol) and iodomethane (1 ml, 16 mmol) were heated together in acetonitrile (10 ml) at reflux for 48 hrs. The mixture was cooled to room temperature and a grey material crystallised out of solution and was filtered off. This was shown to be starting material. The filtrate was diluted with ethyl acetate (200 ml) to give a yellow/green precipitate. The product was filtered off, washed with ethyl acetate and then dried under vacuum. The product was obtained as a yellow/green solid (147 mg, 16.8%).

후처리

  1. temperatureat reflux for 48 hrs
  2. customa grey material crystallised out of solution
  3. filtrationwas filtered off
  4. additionThe filtrate was diluted with ethyl acetate (200 ml)
  5. customto give a yellow/green precipitate
  6. filtrationThe product was filtered off
  7. washwashed with ethyl acetate
  8. customdried under vacuum

출처 및 근거

ORD 기록
ord-220eb2f3f15644d783f300d6b4e22aea
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07579140B2

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