참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | N,N'-di(tert-butyloxycarbonyl)-2-[3-(pyrid-2-yl)isoxazol-5-yl]pyrrolidine-1-carboximidamide | HCID 68814905 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-[3-(Pyrid-2-yl)isoxazol-5-yl]pyrrolidine-1-carboximidamide | HCID 68813167 | 100% |
반응 단계
TFA (30 ml) was added to a cooled solution of N,N′-di(tert-butyloxycarbonyl)-2-[3-(pyrid-2-yl)isoxazol-5-yl]pyrrolidine-1-carboximidamide (Method 39) in DCM (150 ml) at 0° C. The mixture was stirred 0° C. for one hour, allowed to warm to ambient temperature and stirred for a further 18 hours. The volatiles were removed by evaporation and the residue triturated from DCM/ether/hexane. The product was collected by filtration to give the title compound (2.2 g, >100%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07579349B2 |
|---|
| 출처 데이터셋 | uspto-grants-2009_08 |
|---|
| ORD ID | ord-8dc3eb1ef75b4f608fc2a39fd14c2e03 |
|---|
| 출처 메모 | uspto-grants-2009_08 |
|---|
